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What do you know about …. blood brain barrier ?

The brain blood barrier is a barrier between the blood, extracellular means of the brain in the central nervous system.

What do you know about …. blood brain barrier

 brain blood barrier
The barrier consists of a thick basal membrane, in addition to the anterior ends of stellate cells. The barrier is located along the capillaries and is composed of tight conductors that do not exist in the rest of the capillaries.
As endothelial cells, endothelial cells prevent the spread of certain microscopic substances such as bacteria and some large water-loving molecules into the cerebrospinal fluid, while allowing other small, water-distressing molecules to diffuse into liquid (eg, oxygen, carbon dioxide, hormones).
The cells of the barrier effectively transfer some metabolic products such as glucose through the barrier to enter the cerebrospinal fluid and in turn nourish the brain.

Date of discovery

Paul Erlich, a specialist in microbiology, used chemical dyes to illustrate some of the microbial parts under the microscope.
Erlich used the dye of aniline and injected it into the bodies of some animals, but noted that the dye colored all the contents of the organs except the contents of the brain. Erlich did not suggest that the brain did not take this dye.


Later, in 1913 Edwin Goldman, an Erlich student, injected a dye directly into the cerebrospinal fluid of an animal’s brain, and found that the brain had dyed the dye, but the rest of the body did not take the dye. These experiments revealed that there is a kind of separation between the brain and the rest of the body. Scientists have suggested that the blood vessels are responsible for this separation, because there is no tangible barrier between the brain and the rest of the body.
Then the Russian scientist Soft Stern proposed the name (Hematoencephalic Barrier) in 1921
This view remained as it was until the 1960 wafer used a scanner electron microscope and was confirmed and demonstrated the existence of a microscopic barrier.

functions of organs

functions of organs

This barrier results from the “elective” process of conductors between endothelial cells in central nervous system vessels, which prevent the entry of certain solvents into the brain. The endothelial cells are connected to each other by the fixed links, which are made up of small units, and many chemical biochemes such as acetaminates, claudines and the Junctional Assignment Molecule, which are transgenic proteins. These proteins are stabilized with endothelial cells by another protein called zo-1 and some other proteins associated with it.

The brain blood barrier consists of

The brain blood barrier is also made up of high-density cells that block certain substances from passing through the bloodstream through the endothelial cells in the brain bristles more than the bristles of other organs in the body. Stellar stem cells are called cytoskeletal stem cells that surround the endothelial cells of the cerebral blood barrier and are a source of biochemical support for these cells. This barrier can be distinguished from the blood-cerebrospinal fluid barrier, which is a function of choroidal cells in the choroid plexus, and can be distinguished from the retinal blood barrier, which is part of these barriers
There are some parts of the human brain that are not covered by the cerebral blood barrier. These parts include the ventricular parts, for example: the third and fourth ventricle capillaries, capillaries in the pineal gland in the interstitial capillary roof, and the pineal gland that secrete melatonin directly into the blood.


some experiments were carried out during the 1920 m and suggested that the cerebral blood barrier in newborns was immature. The reason for this fallacy is a methodology error (Altnadahi pressure was very high and fetal blood vessels were so accurate that they were partially damaged). Experiments later shown after decreasing the amount of liquid injected that the markings could not bypass the cerebral hematoma. These experiments said that natural materials such as albumin, alpha-1-Vito protein or transverrine with a high concentration of the newborn photographer cannot be detected in fluid outside the cell in the brain. Created B. The diabetic proteins responsible for the output in the transport of the embryonic lining.

The newborn brain lining in the rabbit and the adult rat are identical

Measuring the rate of brain intake of alasitamayd materials, Walanti pyridine, Webnzail, Walbiotanol, Caffeine, Walsitozin, biphenyls haydantoin, ethanol, ethylene glaikol, heroin, walmanitol, methanol, wevinobarbital, propylene Glaikol, Wethiouria and urea.
Contrary to the suggestions that the barrier has not matured in newborns, these studies have shown that the barrier is developed and effective since birth

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